Spinal Tolerance and Dependence: Some Observations on the Role of Spinal N-Methyl-D-Aspartate Receptors and Phosphorylation in the Loss of Opioid Analgesic Responses

The continuous delivery of opiates can lead to a reduction in analgesic effects.In humans, as in other animals, some component of this change in sensitivity seems likely to have a strong pharmacodynamic component.Such loss of effect, deemed to be tolerance in the present article, can be readily demonstrated in animals with repeated bolus and contin

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